Introduction to Biomedical Optics: From Theory to Applications

By Dr. Uttam M. Pal | IIITDM Kancheepuram

Learners enrolled: 590

Learning objectives:
The key objectives of this course are to:

▪ Detailed understanding on optics fundamentals, light-tissue interaction, molecular spectroscopy.

▪ Understand phenomena such as scattering, absorption, fluorescence, and polarization, and how these properties can be utilized in biomedical diagnostics and imaging.

▪ Learn photon transport equation in turbid media, diffusion theory approximation, and Monte Carlo methods for solving inverse problems. Different configurations of near-infrared spectroscopy, such as continuous wave, frequency domain, and time-domain.

▪ Provide hands-on experience in optical instrumentation and characterization of optical tissue phantom that mimics optical properties of biological tissues.

Learning outcomes:

On successful completion of the course, the student will be able to:

▪ Acquire fundamental understanding of the optical instruments (optical components, source, and detectors).

▪ Analyze the underlying mathematical model of the light-tissue interaction and the optical techniques to quantify tissue physiological attributes.

▪ Design and analyze optical systems and its instrumentation to apply in the field of biomedical engineering.

▪ Perform the experiment, acquire data, and interpret the parameters related to light-tissue interaction.

▪ Independently develop optical phantom tissue, perform the optical experiment, acquire data, and troubleshoot practical problems related to light-tissue interaction.

Summary

Course Status :	Upcoming
Course Type :	Elective
Duration :	Self Paced
Category :	Multidisciplinary
Level :	Undergraduate/Postgraduate

Page Visits

Course layout

Module 1: Physics of Biomedical Optics: Introduction to Wave Optics, Fundamentals of Spectroscopy.

Module 2: Light-Tissue Interaction: Scattering Theory: Rayleigh and Mie Scattering. Absorption Theory using Beer Lambert and Modified Beer Lambert Law.

Module 3: Light Transport Theory in Turbid Media: Boltzmann transport equation and Light Transport Modeling and Simulation

Module 4: Optical Instrumentation: Light Sources: Working principle of LASERs and LEDs. Optical lens and Polarizers. Working principal of Light Detectors, Fiber optics, Polarizers. Advance topics such as Raman spectroscopy, fluorescence spectroscopy, optical biosensors, Doppler spectroscopy.

Module 5: Experimental Methods and Multimodal Imaging Techniques: Forward and inverse method for diffuse optical imaging and tomography. Multimodal Imaging Techniques such as Opto-acoustics, opto-thermo, and opto-thermo-acoustic (OTA) modality.

Books and references

1.“Fundamentals of Biomedical Optics: From light interactions with cells to complex imaging systems”, Caroline Boudoux, Blurb, (2022).

2.“Quantitative Biomedical Optics Theory, Methods, and Applications”, Irving J. Bigio and Sergio Fantini, Cambridge Texts in Biomedical Engineering (2016).

3."Biomedical Optics: Principles and Imaging" Lihong V. Wang and Hsin-i Wu, Wiley (2007).

4.“An Introduction to Biomedical Optics” Robert Splinter and Brett A. Hooper, CR Press (2007).

5."Tissue Optics: Light Scattering Methods and Instruments for Medical Diagnosis" Valery Tuchin, SPIE press book (2006).

Instructor bio

Dr. Uttam M. Pal

IIITDM Kancheepuram

Uttam is an Assistant Professor in Biomedical Engineering Stream, Department of Sciences and Humanities, IIITDM Kancheepuram-Chennai. He obtained his Ph.D. from the Department of Electronic Systems Engineering, IISc Bangalore in 2021, where he worked on the design and development of novel multimodal cancer diagnosis systems using optical, thermal, and acoustic modalities. His M.Tech is from the Electrical Department, IIT Bombay in 2013, where he has specialized on computational electromagnetics. He has more than 8 years of industrial experience while working as Team Lead (High-Frequency Electromagnetics) at COMSOL Multiphysics (6 + years), Patent research engineer at Evalueserve (1 year), and Technology Analyst at an opto-semiconductor startup: De Core Science and Technologies (~ 1 year). His research interest lies in developing novel optical tools for intraoperative cancer margin assessment and diagnosis of disease (breast cancer and oral cancer).

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