Human Genetics

By Prof. N. B. Ramachandra   |   Department of Studies in Genetics and Genomics, University of Mysore
The study of human genetics can be intellectually fascinating, but it also has plenty of practical applications. From the use of DNA in court cases to the discovery of new therapies for genetic diseases, a thorough understanding of the human genome can have important medical, social and legal impacts. Understanding the genetic basis behind human disease is one of the most important reasons for studying the human genome. While many genetic disorders are not treatable, early diagnosis can help improve the quality of life or even extend the lifespan of sufferers. 

Current clinical trials on genetic therapies offer the promise of eventual treatments that may give sufferers a life free of symptoms. Diagnostic tests can help couples decide whether to risk passing on specific disease-related genes to their children. Tests assist in vitro fertility doctors to specifically select embryos that do not carry the dangerous gene.

Learners enrolled: 2526


Course Status : Ongoing
Course Type : Elective
Duration : 12 weeks
Start Date : 06 Jul 2020
End Date : 29 Nov 2020
Exam Date : 25 Mar 2021
Enrollment Ends : 14 Oct 2020
Category :
  • Biological Sciences & Bioengineering
  • Level : Undergraduate

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                      Weekly Lecture Topics


    Week 1

    Episode 1

    1 Introduction

    Episode 2

    2 Dermatoglyphics 1

    Episode 3

    3 Dermatoglyphics 2

    Week 2

    Episode 4

    4. Pedigree analysis 1

    Episode 5

    5. Pedigree Analysis 2

    Episode 6

    6 Chromosomes

    Week 3

    Episode 7

    7. Heterochromatin

    Episode 8

      8. Ultrastructure of Chromosome

    Episode 9

      9. Human Karyotype

    Episode 10

    10 Banding techniques

    Week 4

    Episode 11

    11. Euploidy and monoploidy

    Episode 12

    12. Haploidy and polyploidy

    Episode 13

    13. Anueploidy and nondisjunction

    Episode 14

    14. Deletions with examples

    Week 5

    Episode 15

    15. Duplications with examples

    Episode 16

    16. Inversions with examples

    Episode 17

    17. Translocations with examples

    Episode 18

    18. Evolutionary significance of Chromosomal  aberrations

    Week 6

    Episode 19

    21 Genetic disease and inheritance pattern

    Episode 20

    22.a)Autosomal dominant inheritance

    Episode 21

    22.b)Autosomal recessive inheritance

    Week 7

    Episode 22

    23. X- and Y-linked inheritance

    Episode 23

    24. Multifactorial &mito diseases

    Episode 24

    25. Oncogenetics

    Week 8

    Episode 25

      26.Tumour suppressor  genes

    Episode 26

      27.Cells of immune system

    Episode 27

    28. Genetics of immune system

    Week 9

    Episode 28

    29. Innate adaptive immunity & I response

    Episode 29

    30. Inherited Immunodeficiency

    Episode 30

    31.a) HGPs

    Episode 31

    31.b) HGPs

    Week 10

    Episode 32

    32.Genetic markers-SNPs and applications

    Episode 33

    33. Genetic markers-CNVs and InDels and their implications

    Episode 34

    34. Prenatal disgnosis- Non-invasive methods

    Episode 35

    35. Prenatal diagnosis- Invasive method

    Week 11

    Episode 36

    36. Technology in reproductive assistance

    Episode 37

    37. Gene therapy with reference to hemophilia        

    Episode 38

    38.Cord blood banking and stem cell therapy

    Week 12

    Episode 39

    39.Genetic counseling

    Episode 40

    40. Eugenics- positive and negative implications



    1. Brooker, R. J. 2014. Genetics: Analysis and Principles. 5th edition. McGraw Hill.

    2. Cavalli-Sforza L.L., Piazza A., Menozzi P. (1994) History and geography of genes. (Princeton University Press, Princeton, NJ).

    3. Cummings, M. R. 2014. Human Heredity: Principles and Issues. West Publishing Company.

    4. Gardner E. J. M. J. Simmons and D.P. Snustad. 2006 Principles of Genetics. 8th edition. John Wiley & Sons. INC. New York

    5. Griffiths A J F, H. J. Muller, D. T. Suzuki, R. C. Lewontin and W. M. Gelbart. An introduction to genetic analysis.2015. 11th edition. W. H. Greeman. New York.

    6. Harpending H., Sherry S.T., Rogers A.R., Stoneking M.(1993) The genetic structure of ancient human populations. Curr. Anthropol. 34:483–496.

    7. Simmons S 2006, Principles of genetics, 4th Edition, John Wiley & Sons (Asia)  Pte Ltd. New Jersey.

    8. Strickberger M. W.  2012. Genetics. Mac Millan Publishing Co. NewYork

    9. Tamarin, R H. 2009. Principles of Genetics. McGraw-Hill.

    Image sources:

    • https://www.gettyimages.in/detail/news-photo/circa-400-bc-hippocrates-an-ancient-greek-physician-and-the-news-photo/51242244

    • https://www.britannica.com/biography/Aristotle

    • https://commons.wikimedia.org/wiki/File:William_Bateson.jpg

    • https://www.researchgate.net/figure/Spectral-karyotyping-SKY-of-the-metaphase-spread-showing-derXtXq2p_fig2_281389775

    • https://www.ucl.ac.uk/~ucapikr/projects/Ana_staining_LitRev.pdf

    • https://www.researchgate.net/figure/Cytogenetic-analysis-G-banding-karyotype-from-a-peripheral-blood-metaphase-of-the_fig1_235520522

    • https://www.ucl.ac.uk/~ucapikr/projects/Ana_staining_LitRev.pdf                                      

    • https://www.britannica.com/biography/Gregor-Mendel


    Prof. N. B. Ramachandra

    Department of Studies in Genetics and Genomics, University of Mysore
    Prof. NB Ramachandra completed his Ph.D. from University of Mysore and postdoctoral studies from McMaster University, CANADA from 1990-1992 and Worked as Senior Research Associate II  at Univ. of California, Los Angeles, USA from 1999-2000. He is currently the Professor and Chairman, Department of Studies in Genetics and Genomics University of Mysore. He has published more than 150 papers in International journals and during 2016, he served as the Local Secretary for 103rd Indian Science Congress conducted at the University of Mysore. He is the recipient of  several awards including University of Mysore Golden Jubilee foundation award, the two state  and one national science awards. He is an Elected Fellow of Indian Academy of Sciences, FASc.2017.

    He has 28 years of teaching in the various fields of Genetics in University of Mysore and other Universities and Institute. More details one see his profile in his web page: http://www.ramachandralab.com


    Assessment/Assignment marks will be considered for Internal Marks and will carry 30 percent for overall Result.

    End Term Exam- will have 100 questions and will carry 70 percent of  overall Result.

    *All students, who obtain 40% marks in in-course assessment and 40% marks in end-term proctored exam separately, will be eligible for certificate and credit transfer.