Human Genetics

By Prof. N. B. Ramachandra   |   Department of Studies in Genetics and Genomics, University of Mysore
Learners enrolled: 2526
The study of human genetics can be intellectually fascinating, but it also has plenty of practical applications. From the use of DNA in court cases to the discovery of new therapies for genetic diseases, a thorough understanding of the human genome can have important medical, social and legal impacts. Understanding the genetic basis behind human disease is one of the most important reasons for studying the human genome. While many genetic disorders are not treatable, early diagnosis can help improve the quality of life or even extend the lifespan of sufferers. 

Current clinical trials on genetic therapies offer the promise of eventual treatments that may give sufferers a life free of symptoms. Diagnostic tests can help couples decide whether to risk passing on specific disease-related genes to their children. Tests assist in vitro fertility doctors to specifically select embryos that do not carry the dangerous gene.
Course Status : Completed
Course Type : Elective
Duration : 12 weeks
Start Date : 06 Jul 2020
End Date : 29 Nov 2020
Exam Date : 25 Mar 2021 IST
Enrollment Ends : 14 Oct 2020
Category :
  • Biological Sciences & Bioengineering
Credit Points : 4
Level : Undergraduate

Page Visits

Course layout


                  Weekly Lecture Topics


Week 1

Episode 1

1 Introduction

Episode 2

2 Dermatoglyphics 1

Episode 3

3 Dermatoglyphics 2

Week 2

Episode 4

4. Pedigree analysis 1

Episode 5

5. Pedigree Analysis 2

Episode 6

6 Chromosomes

Week 3

Episode 7

7. Heterochromatin

Episode 8

  8. Ultrastructure of Chromosome

Episode 9

  9. Human Karyotype

Episode 10

10 Banding techniques

Week 4

Episode 11

11. Euploidy and monoploidy

Episode 12

12. Haploidy and polyploidy

Episode 13

13. Anueploidy and nondisjunction

Episode 14

14. Deletions with examples

Week 5

Episode 15

15. Duplications with examples

Episode 16

16. Inversions with examples

Episode 17

17. Translocations with examples

Episode 18

18. Evolutionary significance of Chromosomal  aberrations

Week 6

Episode 19

21 Genetic disease and inheritance pattern

Episode 20

22.a)Autosomal dominant inheritance

Episode 21

22.b)Autosomal recessive inheritance

Week 7

Episode 22

23. X- and Y-linked inheritance

Episode 23

24. Multifactorial &mito diseases

Episode 24

25. Oncogenetics

Week 8

Episode 25

  26.Tumour suppressor  genes

Episode 26

  27.Cells of immune system

Episode 27

28. Genetics of immune system

Week 9

Episode 28

29. Innate adaptive immunity & I response

Episode 29

30. Inherited Immunodeficiency

Episode 30

31.a) HGPs

Episode 31

31.b) HGPs

Week 10

Episode 32

32.Genetic markers-SNPs and applications

Episode 33

33. Genetic markers-CNVs and InDels and their implications

Episode 34

34. Prenatal disgnosis- Non-invasive methods

Episode 35

35. Prenatal diagnosis- Invasive method

Week 11

Episode 36

36. Technology in reproductive assistance

Episode 37

37. Gene therapy with reference to hemophilia        

Episode 38

38.Cord blood banking and stem cell therapy

Week 12

Episode 39

39.Genetic counseling

Episode 40

40. Eugenics- positive and negative implications

Books and references


  1. Brooker, R. J. 2014. Genetics: Analysis and Principles. 5th edition. McGraw Hill.

  2. Cavalli-Sforza L.L., Piazza A., Menozzi P. (1994) History and geography of genes. (Princeton University Press, Princeton, NJ).

  3. Cummings, M. R. 2014. Human Heredity: Principles and Issues. West Publishing Company.

  4. Gardner E. J. M. J. Simmons and D.P. Snustad. 2006 Principles of Genetics. 8th edition. John Wiley & Sons. INC. New York

  5. Griffiths A J F, H. J. Muller, D. T. Suzuki, R. C. Lewontin and W. M. Gelbart. An introduction to genetic analysis.2015. 11th edition. W. H. Greeman. New York.

  6. Harpending H., Sherry S.T., Rogers A.R., Stoneking M.(1993) The genetic structure of ancient human populations. Curr. Anthropol. 34:483–496.

  7. Simmons S 2006, Principles of genetics, 4th Edition, John Wiley & Sons (Asia)  Pte Ltd. New Jersey.

  8. Strickberger M. W.  2012. Genetics. Mac Millan Publishing Co. NewYork

  9. Tamarin, R H. 2009. Principles of Genetics. McGraw-Hill.

Image sources:

  • https://www.gettyimages.in/detail/news-photo/circa-400-bc-hippocrates-an-ancient-greek-physician-and-the-news-photo/51242244

  • https://www.britannica.com/biography/Aristotle

  • https://commons.wikimedia.org/wiki/File:William_Bateson.jpg

  • https://www.researchgate.net/figure/Spectral-karyotyping-SKY-of-the-metaphase-spread-showing-derXtXq2p_fig2_281389775

  • https://www.ucl.ac.uk/~ucapikr/projects/Ana_staining_LitRev.pdf

  • https://www.researchgate.net/figure/Cytogenetic-analysis-G-banding-karyotype-from-a-peripheral-blood-metaphase-of-the_fig1_235520522

  • https://www.ucl.ac.uk/~ucapikr/projects/Ana_staining_LitRev.pdf                                      

  • https://www.britannica.com/biography/Gregor-Mendel

Instructor bio

Prof. N. B. Ramachandra

Department of Studies in Genetics and Genomics, University of Mysore
Prof. NB Ramachandra completed his Ph.D. from University of Mysore and postdoctoral studies from McMaster University, CANADA from 1990-1992 and Worked as Senior Research Associate II  at Univ. of California, Los Angeles, USA from 1999-2000. He is currently the Professor and Chairman, Department of Studies in Genetics and Genomics University of Mysore. He has published more than 150 papers in International journals and during 2016, he served as the Local Secretary for 103rd Indian Science Congress conducted at the University of Mysore. He is the recipient of  several awards including University of Mysore Golden Jubilee foundation award, the two state  and one national science awards. He is an Elected Fellow of Indian Academy of Sciences, FASc.2017.

He has 28 years of teaching in the various fields of Genetics in University of Mysore and other Universities and Institute. More details one see his profile in his web page: http://www.ramachandralab.com

Course certificate

Assessment/Assignment marks will be considered for Internal Marks and will carry 30 percent for overall Result.

End Term Exam- will have 100 questions and will carry 70 percent of  overall Result.

*All students, who obtain 40% marks in in-course assessment and 40% marks in end-term proctored exam separately, will be eligible for certificate and credit transfer.

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