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MOLECULAR BIOLOGY

By Dr. Nayan K. Jain   |   Department of Life-Science,University School of Sciences, Gujarat University, Ahmedabad, India
Learners enrolled: 2855

The current core course has been specifically planned for the students studying in the arena of Zoology subject at College or University level as per the UGC approved curriculum. In addition, this particular core course can also be adopted by undergraduate students studying in the relevant disciplines of Biological Sciences encompassing Life-Science, Biochemistry, Biotechnology, Genetics, Biomedical Technology, Forensic Science, Pharmaceutical Sciences, Cancer Biology, Clinical Research, Microbiology, Bioinformatics, Paramedical as well as Medical fields.

The present core course has been organized magnificently to cover all the essential aspects related to Molecular Biology field. The course will provide a brief overview of Nucleic acid background comprising of salient features and models of DNA and RNA. The course will mainly focus on the study of principal molecular events of cell incorporating DNA Replication, Transcription and Translation in prokaryotic as well as eukaryotic organisms. The course will also emphasize Post Transcriptional Modifications and Processing of Eukaryotic RNA covering the concepts of Split genes, Introns, Exons, Splicing Mechanisms and RNA Editing. The course will also impart detailed explanation of Prokaryotic and Eukaryotic Transcriptional Regulation along with mechanism of Gene Silencing. During this course, the students will be imparted comprehensive understanding about key concept of DNA Repair Mechanisms. In addition, the course will provide glimpse of Ribo-switches, RNA Interference, miRNA and siRNA as a part of different types of Regulatory RNAs. The course will also provide the additional knowledge regarding various aspects of molecular biology in the form of supplementary study material.

Course Objectives:

The structure of the present core course on Molecular Biology has been magnificently designed with the perspective to achieve following key objectives:

To provide comprehensive background of Salient features of Nucleic Acids and DNA model to the course learners.

To impart detailed understanding of key events of molecular biology comprising of mechanism of DNA Replication, Transcription and Translation in Prokaryotes and Eukaryotes.

To provide adequate knowledge about Post Transcriptional Modifications and Processing of Eukaryotic RNA to the course learners.

To give detailed explanation of Transcriptional Regulation with examples of lac operon and tryptophan operon in prokaryotic as well as eukaryotic organisms along with key concept of Gene Silencing to the course learners.

To develop comprehensive understanding regarding DNA Repair Mechanisms in the course learners.

To provide glimpse of types of Regulatory RNAs by imparting adequate information about Ribo-switches, RNA Interference, miRNA and siRNA to the course learners.


Eligibility for Enrollment:

Those students who have passed (10+2) with Biological Science subject with at least 55% marks and/or at present studying Zoology at undergraduate level.


Course Pre-requisite:

Pre-requisite for admission in this course will be (10+2) with any Biological Science with at least 55% marks.


Intended Audience:

The  course has been intended for the students studying in the arenas of relevant biological science disciplines encompassing Life-Science, Biochemistry, Biotechnology, Genetics, Bioinformatics, Microbiology, Forensic Science, Environmental Science, Biomedical Technology, Cancer Biology, Clinical Research, Pharmaceutical Sciences, Cancer Biology, Medical Science and Paramedical fields.

Reading Materials:

References and Web links have been provided in all the modules.


Learning Outcomes:

After successful accomplishment of the course, the learners will be able to acquire better understanding and comprehensive knowledge regarding most of the essential aspects of Molecular Biology subject which in turn will provide a fantastic opportunity to develop professional skill related to the field of molecular biology.
Course Staff:

Sr. No.

Course Instructors

Institute

E-mail Address

1.

DR. NAYAN K. JAIN
Course Co-ordinator
(Principal Investigator)
SWAYAM MOOCs-Molecular Biology
Gujarat University

Department of Life-Science,
University School of Sciences,
Gujarat University,
Ahmedabad-380009, India.

drnj11@yahoo.co.in

2.

DR. FLORA C. SHAH
Teaching Assistant
SWAYAM MOOCs-Molecular Biology
Gujarat University

Department of Life-Science,
University School of Sciences,
Gujarat University,
Ahmedabad-380009, India.

florashah88@gmail.com

Summary
Course Status : Completed
Course Type : Core
Language for course content : English
Duration : 8 weeks
Category :
  • Mathematics
Credit Points : 2
Level : Undergraduate
Start Date : 20 Jul 2020
End Date : 30 Nov 2020
Enrollment Ends : 30 Sep 2020
Exam Date :

Page Visits



Course layout

Unit-1: Nucleic Acids 

Lecture 1: Salient Features of DNA and RNA
Lecture 2: Watson & Crick DNA Model
Lecture 3: Structural Organization of DNA
Lecture 4: DNA Estimation
       
Unit-2: DNA Replication 

Lecture 5: Central Dogma of Molecular Biology
Lecture 6: Prokaryotic DNA Replication
Lecture 7: Eukaryotic DNA Replication  

Unit-3: Transcription 


Lecture 8: Prokaryotic & Eukaryotic Transcription
       
Unit-4: Translation
 
Lecture 9 : Genetic Code & Wobble Hypothesis
Lecture 10: Prokaryotic Translation
Lecture 11: Eukaryotic Translation
Lecture 12: Post Translational Modifications & Protein Synthesis Inhibitors
       
Unit-5: Post Transcriptional Modifications and Processing of Eukaryotic RNA 

Lecture 13: Eukaryotic Post Transcriptional Modifications & RNA Processing

Unit-6: Gene Regulation

Lecture 14: Gene Regulation in Prokaryotes & Eukaryotes

Unit-7: DNA Repair Mechanism

Lecture 15: DNA Repair

Unit-8: Regulatory RNAs 

Lecture 16: Types of Regulatory RNAs

Supplementary Study Material

Supplementary Lecture 17: Genome Information & Sequence Analysis
Supplementary Lecture 18: DNA Isolation
Supplementary Lecture 19: Qualitative Estimation of DNA 
Supplementary Lecture 20: Mutagens and Mutagenicity

Books and references

  • Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter Walter. Molecular Biology of the Cell, 4th edition. New York: Garland Science (2002).
  • Daniel L. Hartl and Maryellen Ruvolo. Genetics: Analysis of Genes and Genomes, 8th Edition. Burlington, Mass.: Jones & Bartlett Learning (2012).
  • Gerald Karp. Cell and Molecular Biology: Concepts and Experiments, 5th Edition. Wiley Publication (2008).
  • Harvey Lodish, Arnold Berk, Paul Matsudaira, Chris A. Kaiser, Monty Krieger, Freeman. Molecular Cell Biology, 5th edition. W. H. & Company (2003).
  • James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick. Molecular Biology of the Gene, 5th edition. Cold Spring Harbor Laboratory Press (2003).
  • Stryer, Lubert. Biochemistry, 2nd Edition. W. H. Freeman and Company, New York (1981).

Instructor bio

Dr. Nayan K. Jain

Department of Life-Science,University School of Sciences, Gujarat University, Ahmedabad, India
DR. NAYAN K. JAIN [B.Sc. (Hon’s), M. Sc., Ph.D., FGSA., FICCE] IS A RENOWNED PROFESSOR & HEAD OF DEPARTMENT OF LIFE-SCIENCE, DIRECTOR OF M. SC. FOOD SCIENCE & NUTRITION COURSE AND CO-ORDINATOR IN DEPARTMENT OF BIOCHEMISTRY, GUJARAT UNIVERSITY, AHMEDABAD, INDIA. HE HAS 30 YEARS OF RESEARCH AND TEACHING EXPERIENCE. HIS AREAS OF EXPERTISE INCLUDE OCULAR BIOCHEMISTRY, MOLECULAR GENETICS, CELL BIOLOGY, ANIMAL BEHAVIOR, MICROSCOPY, ECOLOGY, TOXICOLOGY, PHYSIOLOGY, STEM CELL BIOLOGY AND BIOINSTRUMENTATION. HE HAS MORE THAN 100 RESEARCH PAPERS TO HIS CREDIT PUBLISHED IN NATIONAL AND INTERNATIONAL PEER-REVIEWED REFEREED JOURNALS. HE WAS ASSIGNED AS THE ‘SUBJECT CO-ORDINATOR’ AND ‘SUBJECT EXPERT’ FOR E-CONTENT DEVELOPMENT RELATED TO EDUCATIONAL PROGRAMMES FOR THE SUBJECTS OF ZOOLOGY AND LIFE-SCIENCE SPONSORED BY UGC-CEC AS A PART OF NME-ICT PHASE-I & II PROJECT. DR. JAIN WAS ASSIGNED AS A ‘PRINCIPAL INVESTIGATOR’ BY GOVERNMENT OF INDIA FOR MHRD SPONSORED SWAYAM MOOCs OF DEVELOPMENTAL BIOLOGY, PRINCIPLES OF ECOLOGY, PRINCIPLES OF GENETICS, EVOLUTIONARY BIOLOGY AND MOLECULAR BIOLOGY COURSES. HE HAS ALSO WORKED FOR THE PRESTIGIOUS POSTS OF EX-REGISTRAR (I/C) AS WELL AS EX-DIRECTOR (I/C) OF EMRC, GUJARAT UNIVERSITY. DR. JAIN HAS REMAINED ACTIVELY ENGAGED IN VARIOUS EDUCATIONAL AND ADMINISTRATIVE ACTIVITIES OF SEVERAL STATE AND CENTRAL UNIVERSITIES. HE HAS ALSO BEEN ASSOCIATED WITH ESTEEMED GUJARAT SCIENCE ACADEMY AS A MEMBER SECRETARY FOR CO-ORDINATION OF SIGNIFICANT SCIENTIFIC EVENTS.

Course certificate

All the course learners will be awarded "Course Credit Certificate" from SWAYAM, Ministry of Human Resource and Development (MHRD), Government of India after successful completion of the MOOCs on Molecular Biology.



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