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Organic Chemistry 1

By Dr. B. S. Balaji   |   Jawaharlal Nehru University
Learners enrolled: 2688

This course is a 4 credit course (15 weeks, 40 module) for M. Sc. Chemistry Students. Here, Students will be trained to improve their factual, conceptual, procedural and metacognitive knowledge. The scientific explanation given in the video contents makes use of the following components: Presentations, chemical structures, figures, tables, images, 3D-animations, white board demonstration, use of molecular models, paper 3D-models, mirrors etc. We gave emphasis to instructional design by leveraging theories based on Malcom  Knowels Andragogy, modified Bloom’s taxonomy, the Feynman Technique, ADDIE model, Dick and Carey model, neuro slide design principles etc. 

Who can benefit Any student or learner who wants to learn the basics of organic chemistry. The course shall be helpful for PG students (credit transfer), research scholars, young scientists and faculty members for their career growth. 3rd year UG students who are in pursuit of excellence can learn more from this course. The course covers most of the topics (organic chemistry) that are part of various competitive exams. IIT-JAM, CSIR-NET, GATE, UPSC, SLET, SSC-CGL, various CET. Industry support for jobs pharma, petrochemical, dye, perfume, agro chemicals industries
Summary
Course Status : Ongoing
Course Type : Core
Duration : 15 weeks
Start Date : 18 Jan 2021
End Date : 30 Apr 2021
Exam Date :
Enrollment Ends : 28 Feb 2021
Category :
  • Chemistry
Credit Points : 4
Level : Postgraduate



Course layout

We are happy to announce that this course has been very popular among learners. Earlier enrollments for this course: July 2019 - 3591 Jan 2020 - 3224 Aug 2020 - 2666 Students achievements: Shubham Pol: GPAT and NIPER- JEE qualified Suryakant Mishra: IIT-JAM qualified Sourav Adak: CSIR qualified Learner's Feedback: 


"This course is very great and is helpful not only for students but also for all chemistry professors. This course is the best platform for all organic chemistry learners. The language is very easy. So that, each and every student can understand all the concepts easily. Discussion forum is also a best platform for us to ask any query about any concept.

Thank you very much sir for excellent teaching, clearing every concept in organic chemistry from basic and giving assignments to us. Keep it up sir.

Also,thanks to SWAYAM for conducting such type of course for all chemistry learners." ---- Ketaki, One of the topper from the course July-2019.


 "The classes are very explanatory and very useful for the PG students and also for the faculty members. I really appreciate the efforts taken by Balaji sir. " ---Seethalakshmi S



"The course content was so relevant and insightful that every individual would definitely benefit hugely from it for their career in chemistry. The classes are very vivid, crystal clear and knowledgeable. I am very fortunate to be part of this course." ---- Ramakrishna S



"Professor Balaji did splendid job and did lots of efforts. Its been 15 days to the course have started and I am taking it right now. This course is beneficial to all as the professor took the course from basics to advance, this make learning very easy & he is very responsive which makes it very convenient." ----- Simran K

        


"very good nd well qualified professors.

for solving gate, net questions, dis course iz useful.  thanku for efforts of all professors". ---- Anonymous




  

Syllabus

Week 1 

Introduction to stereochemistry

Conformational analysis of open chain systems 



Week 2 

Conformational analysis of cyclic systems

Symmetry elements, Point group analysis

Stereochemical conventions 


Week 3 

Stereogenicity, Topicity

ORD and CD, Axial halo ketone rule, Octant Rule


Week 4

Stereochemical reactions

Reactions involving stereo centres

Crams Rule, Felkin-Anh model, Prelog rules


Week 5

Aromaticity, Aromatic stabilization energy, Hückel MO, Musulin-Frost diagram 

Polycyclic aromatic hydrocarbon (PAH), Polyacenes, Annulene


Week 6 

Aromatic Electrophilic substitutions

Aromatic Nucleophilic substitutions 

Ipso-cine-tele substitution


Week 7

Reaction dynamics, Hammond postulate 

Linear free energy relationship, Hammett equation


Week 8

Yukawa Tsuno equation, Swain-Lupton equation, Grunwald–Winstein equation, Taft equation 

Curtin-Hammett principle, Winstein-Holness equation 

Carbocation, Part 1: Generation, Structure and Geometry


Week 9

Carbocation, Part 2: Stabilisation of carbocation, Reactions

Carbocation, Rearrangement 1: No Change in carbon skeleton, Change in carbon skeleton 

Carbocation, Rearrangement 2: involvement of other electron deficient terminus, Anchimeric assistance


Week 10

Carbanions: pKa and its significance

Carbanions: Hard and Soft Acid and Base principle

Carbanions: Structure, Formation, Stability, Reactivity


Week 11

Carbanion reactions: Acyl Anions, Benzoin condensation, Umpolung-inversion of reactivity

Free radical 1: Formation, Structure, Stability



Week 12

Free radical 2: Stability, Reactivity

Free radical 3: Reactions: Addition, atom abstraction, disproportionation, cyclisation



Week 13

Free radical 4: Reactions: Fenton, Kolbe, Bouveault-Blanc, Giese, Hofmann-Loffler, Birch, Barton-McCombie, Sandmeyer, Barton decarboxylation

Carbene, Nitrene: Generation, Structure, Reactivity



Week 14

Carbonyl addition reaction 

Enol and enolate formation and reactions

Enamines formation and reactions



Week 15

Enol ethers formation and reactions, Mukaiyama-Aldol reaction

Sharpless epoxidation, Click reaction, Diels-Alder reaction- Scope and mechanism



Exam


Books and references

March's Advanced Organic Chemistry Reactions, Mechanisms and Structure 5th Ed. Michael B. Smith, Jerry March, John Wiley & Sons, Inc., 2001.

F. A. Carey: Organic Chemistry, 5th  Ed., McGraw-Hill, 2004.

Peter Sykes, A Guidebook to Mechanism in Organic Chemistry, 6th Ed, John Wiley and Sons. Inc, New York, 1986.

J. Clayden, N. Greeves, S. Warren, Organic Chemistry, 2nd Ed., Oxford University Press, New Delhi, 2012.

F. A. Carey and R. J. Sundberg, Advanced Organic Chemistry, Part A & B, 5th  Ed., Springer, New York, 2007.

Thomas H. Lowry and Kathleen Schueller Richardson, Mechanism and theory in Organic Chemistry, Harper& Row, Publishers, 1976.

Paula Yurkanis Bruice, Organic Chemistry, 4th Ed. Prentice Hall, 2003.

Arvi Rauk, Orbital Interaction Theory of Organic Chemistry, 2nd Ed., John Wiley & Sons, Inc., 2001.

D. Nasipuri, Stereochemistry of organic compounds, Principles and Applications, 3rd Ed. New Age International Publishers, 2018.

P. S. Kalsi, Stereochemistry: Conformation and Mechanism, 9th Ed, New Age International (P) Ltd., 2017.

Ernest L. Eliel, Samuel H. Wilen, Stereochemistry of Organic Compounds, Wiley India Ed, 2008.

I. L. Finar, Organic Chemistry, Volume 2: Stereochemistry and The Chemistry of Natural Products, Chapter 2, 5th Ed, Pearson Education India, 1956.


Instructor bio

Dr. B. S. Balaji

Jawaharlal Nehru University

Dr. Balaji served as subject matter expert/external Academic consultant to e-VidyaBharati/ ArogyaBharati project of Ministry of External affairs, Government of India in collaboration with National Institute for Smart Governance. 

Dr. Balaji is working as Associate Professor at School of Biotechnology, Jawaharlal Nehru University. His area of specialization includes Green chemistry, synthetic chemistry, drug development, nano-chemistry, teaching and learning methodologies. He received his Ph.D in organic Chemistry from National Chemical Laboratory, Pune, affiliated to then Pune University. He spent three years as a Center of Excellence Foreign Visiting researcher at Hokkaido University, Sapporo, Japan. He then worked as Postdoctoral fellow and Research fellow (faculty track position) at University of Missouri, Columbia, USA for five years. He has published 18 research publications (including a book) and holds four Indian patents. The research contribution from his laboratory had appeared in a few Journal cover pages (Chemical Communication, Nuclear Medicine and Biology) and appeared in local print and electronic media. He got his MBA from Anna University with Technology management as specialization.

He has been regularly contributing as a resource person for various Faculty development program to School, College and University faculty members. So far he had trained over 1000 Faculty members.


Course certificate

“30 Marks will be allocated for Internal Assessment and 70 Marks will be allocated for external proctored examination”


There will be weekly graded evaluation. To get a certificate, you have to attempt weekly graded crossword puzzle 30% weight (best 6 out of 15 graded puzzle) and final proctored examination 70% weight.


Best of 6 out of 15 graded quizzes/crossword puzzles will be considered for internal evaluation. The selection of 6 best quizzes will be spread over the entire 15 weeks. We will select 2 best quizzes from Week 1 to 5, another two from Week 6-10 and last two from Week 11-15.




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