Human Population Genetics

By Dr. Manzoor Ahmad Mir   |   University of Kashmir
Learners enrolled: 625

The course on “Human Population Genetics” is a Discipline Specific Elective Course in Anthropology at undergraduate (UG) level under the Choice Based Credit System (CBCS) of UGC having 4 credits. This is an introductory course designed primarily for students in the undergraduate or master’s programs interested in biomedical research, genetic counselling, medicine, and clinical genetics. This course is expected introduce the rapid advancements in our understanding the role of human population genetics in health and disease. The course is specially designed to supplement and enhance the understanding of students about different dimensions of human population genetics starting from Mendals laws to genetic polymorphism, mutations in genes to linkage, to evolutionary genetics to evolution of humans, The MOOC content will also shed light on the Population genetics and disease association, genetic markers in forensic science, Hardy Weinberg law, Multiple Allelism, codominance, Epistasis, migration, selection, genetic variance and Human ape comparisons This MOOC is designed to help you to learn about the fundamental bases of population and evolutionary genetics, understanding of the demographic history of our species, including how modern human populations have dispersed around the globe, how population sizes have changed over time and the extent to which they have admixed. This will provide you a basic knowledge on population genetics, the study of human migrations and human adaptation to extreme conditions. Further you will be able to discover the genetic diversity of our species, its causes and consequences, to identify how humans have adapted to the great diversity of environments and the importance of the Neanderthal genome in our genetic heritage. 

This MOOC is aimed at anyone who wishes to learn more about Population genetics and human evolution. It is of particular interest for students working in the field of biomedical sciences, genomics, anthropology, genetics, Zoology, Biotechnology, Evolutionary Biology etc. Once this course, is completed by a student he/she will be equipped with basic and classical knowledge of human population genetics, classical and advanced genetics and will be able to take up any advanced post graduate programmes based on genetics such as medical genetics, developmental and behavioural genetics, bioinformatics, environmental genetics, genomics etc.

Course Status : Ongoing
Course Type : Elective
Duration : 12 weeks
Start Date : 30 Jan 2023
End Date : 22 Apr 2023
Exam Date :
Enrollment Ends : 15 Mar 2023
Category :
  • Biological Sciences & Bioengineering
Credit Points : 4
Level : Undergraduate

Page Visits

Course layout


Landmarks in the history of genetics

Principles in human genetics

Single locus (Mendelian) versus multi-locus (quantitative/complex) inheritance

Chromosome theory of inheritance (segregation and independent assortment)


Mendelian Inheritance Single factor and multifactorial inheritance, polygenic inheritance),

Non- Mendelian inheritance (Multiple Allelism, Co-dominance and incomplete dominance”

Sex linked, epistasis; penetrance and expressivity;

Cytoplasmic inheritance


Introduction to Ecological Genetics and Polymorphism

Phenotypic & genotypic polymorphisms

Transient polymorphism

Balanced   polymorphisms


Models explaining the maintenance of genetic polymorphism

Relationship between sickle cell and malaria,

X-linked polymorphism,

Selection due to infectious diseases and its association with blood groups and other

Hardy-Weinberg principle


Genotypic and allelic frequencies

Assumptions of Hardy-Weinberg equilibrium

Its applications and exception

Mechanism for dynamics in Gene Frequency



Selection pattern and mechanism

Genetic drift (bottle neck and founder effect),

Gene flow/migration


Inbreeding (inbreeding co-efficient and its genetic consequences)

Population structure and admixture in human populations

Random & non-random mating (positive and negative assortative mating),



Linkage disequilibrium

Genetic markers utility of genetic markers in forensic,

Population and disease association studies

Human evolutionary genetics


From Mendel to molecules

A brief history of evolutionary genetics

Epistasis and the conversion of genetic variances

Human-Ape comparisons


Blood group typing

Colour blindness

Biochemical markers-DNA isolation

Polymerase chain reaction (PCR)


Glucose-6-phosphate dehydrogenase deficiency

PTC tasting ability

Genetic counselling and human population genetics

Human population genetics and Forensics


Assignment’s compilation


Books and references

1. Human Population Genetics 1st Edition, by John H. Relethford, Willey-Blackwell Publishers 2022.

2. Human Population Genomics, Introduction to Essential Concepts and Applications, by Kirk E. Lohmueller, Rasmus Nielsen. Springer Nature Publishers; 2021

3. Principles of Population Genetics; by Danil L Harti and Andrew J Clarke, Oxford University Press Inc, 2006

4. Human Population Genetics, 1st Edition,  by John H. Relethford; Willey and Blackwell Publishers 2012

5. Population Genetics, by Rafael Maia, Intech Open Publishers UK. 2022

6. Human Population Genetics and Genomics, 1st Edition 2018, Elsevier Publishers

5. Human Genetics: Concepts and Applications by Ricki Lewis

McGraw Hill Publishers 2020.

7. Human Population Genetics; A tribute to JBS Haldane; by Partha P. Majumder Springer Nature Publishers, 1993

8. Human Genetics, 6th Edition, SD Gangane, Elsevier Publishers 2021

9. Essentials Of Human Genetics Fifth Edition (University Press)

By Manu L. Kothari, ‎Lopa A. Mehta · 2009

10. Principles of Genetics by EJ Gardner, MA, Simmons and DP Snustad, 8th Edition, Willey Press 2006. 


Dr. Pir Mohd Ishfaq
Department of Bioresources
University of Kashmir

Instructor bio

Dr. Manzoor Ahmad Mir

University of Kashmir

Dr. Manzoor Ahmad Mir holds Master’s Degree in Life Science, qualified CSIR-JRF-NET three times; completed his Ph. D from Jawaharlal Nehru University New Delhi through CSIR-Institute of Microbial Technology Chandigarh in the field of Life Sciences. Dr Manzoor has published more than 50 high-impact research papers with a cumulative impact factor of more than 200, has published 20 books and 56 book chapters with international publishers like Elsevier USA, Springer-Nature, Nova Biomedical Science Publisher USA, IGI Global, etc. Dr. Manzoor has guided eight Ph. D scholars besides 27 Masters Project students. Dr Manzoor has currently two on-going research projects one from SERB-DST Govt of India and one from JKST&IC-DST Govt of J&K. Dr Manzoor has developed Massive Open Online Course (MOOCs) in Immunology and Endocrinology and is currently developing two more MOOC courses on Human Genetics and Human Population Genetics for UGC-CEC-SWAYAM Ministry of Education Govt of India. He is member of many scientific organizations and societies like American Association of Cancer Research, American Oncology association, Fellow of Royal British Society, International Immunology Association, Indian Cancer Society, Indian Immunology Society, etc. He is on the editorial board and Reviewer of many prestigious journals. Dr Manzoor was awarded Teachers Associate Research Excellence Award by DST Govt of India in 2019 and Summer Research Fellowship by Indian Academy of Sciences and National Science Academy in 2020 and was awarded by JKST&IC Department of Science and Technology Govt of J&K for his Breast Cancer Awareness and Research during Kashmir-Expo-2022. Dr Manzoor has visited more than 10 countries for his scientific presentations like USA, China, UK, Spain, UAE etc. He was the first nodal officer and coordinator of Kupwara University Campus and is the coordinator of IIS-Gujrat University Collaboration. Presently he is Head Department of Bioresources, University of Kashmir.

Website: http://bioresources.uok.edu.in/Main/ViewPage.aspx?Page=101 

Course certificate

30% for in-course assessment and 70% for end term proctored exam

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