Human Genetics

By Prof. NB Ramachandra   |   University of Mysore
Learners enrolled: 769
The study of human genetics can be intellectually fascinating, but it also has plenty of practical applications. From the use of DNA in court cases to the discovery of new therapies for genetic diseases, a thorough understanding of the human genome can have important medical, social and legal impacts. Understanding the genetic basis behind human disease is one of the most important reasons for studying the human genome. While many genetic disorders are not treatable, early diagnosis can help improve the quality of life or even extend the lifespan of sufferers. 

Current clinical trials on genetic therapies offer the promise of eventual treatments that may give sufferers a life free of symptoms. Diagnostic tests can help couples decide whether to risk passing on specific disease-related genes to their children. Tests assist in vitro fertility doctors to specifically select embryos that do not carry the dangerous gene.
Course Status : Ongoing
Course Type : Elective
Duration : 12 weeks
Start Date : 09 Jan 2023
End Date : 30 Apr 2023
Exam Date :
Enrollment Ends : 15 Mar 2023
Category :
  • Biological Sciences & Bioengineering
Credit Points : 4
Level : Undergraduate

Page Visits

Course layout


                  Weekly Lecture Topics


Week 1

Episode 1

1 Introduction

Episode 2

2 Dermatoglyphics 1

Episode 3

3 Dermatoglyphics 2

Week 2

Episode 4

4. Pedigree analysis 1

Episode 5

5. Pedigree Analysis 2

Episode 6

6 Chromosomes

Week 3

Episode 7

7. Heterochromatin

Episode 8

  8. Ultrastructure of Chromosome

Episode 9

  9. Human Karyotype

Episode 10

10 Banding techniques

Week 4

Episode 11

11. Euploidy and monoploidy

Episode 12

12. Haploidy and polyploidy

Episode 13

13. Anueploidy and nondisjunction

Episode 14

14. Deletions with examples

Week 5

Episode 15

15. Duplications with examples

Episode 16

16. Inversions with examples

Episode 17

17. Translocations with examples

Episode 18

18. Evolutionary significance of Chromosomal  aberrations

Week 6

Episode 19

21 Genetic disease and inheritance pattern

Episode 20

22.a)Autosomal dominant inheritance

Episode 21

22.b)Autosomal recessive inheritance

Week 7

Episode 22

23. X- and Y-linked inheritance

Episode 23

24. Multifactorial & mito diseases

Episode 24

25. Oncogenetics

Week 8

Episode 25

  26.Tumour suppressor  genes

Episode 26

  27.Cells of immune system

Episode 27

28. Genetics of immune system

Week 9

Episode 28

29. Innate adaptive immunity & I response

Episode 29

30. Inherited Immunodeficiency

Episode 30

31.a) HGPs i.e. Human Genome Projects

Episode 31

31.b) HGPs i.e. Human Genome Projects

Week 10

Episode 32

32.Genetic markers-SNPs and applications

Episode 33

33. Genetic markers-CNVs and InDels and their implications

Episode 34

34. Prenatal diagnosis- Non-invasive methods

Episode 35

35. Prenatal diagnosis- Invasive method

Week 11

Episode 36

36. Technology in reproductive assistance

Episode 37

37. Gene therapy with reference to hemophilia        

Episode 38

38.Cord blood banking and stem cell therapy

Week 12

Episode 39

39.Genetic counseling

Episode 40

40. Eugenics- positive and negative implications

Books and references


  1. Brooker, R. J. 2014. Genetics: Analysis and Principles. 5th edition. McGraw Hill.

  2. Cavalli-Sforza L.L., Piazza A., Menozzi P. (1994) History and geography of genes. (Princeton University Press, Princeton, NJ).

  3. Cummings, M. R. 2014. Human Heredity: Principles and Issues. West Publishing Company.

  4. Gardner E. J. M. J. Simmons and D.P. Snustad. 2006 Principles of Genetics. 8th edition. John Wiley & Sons. INC. New York

  5. Griffiths A J F, H. J. Muller, D. T. Suzuki, R. C. Lewontin and W. M. Gelbart. An introduction to genetic analysis.2015. 11th edition. W. H. Greeman. New York.

  6. Harpending H., Sherry S.T., Rogers A.R., Stoneking M.(1993) The genetic structure of ancient human populations. Curr. Anthropol. 34:483–496.

  7. Simmons S 2006, Principles of genetics, 4th Edition, John Wiley & Sons (Asia)  Pte Ltd. New Jersey.

  8. Strickberger M. W.  2012. Genetics. Mac Millan Publishing Co. NewYork

  9. Tamarin, R H. 2009. Principles of Genetics. McGraw-Hill.

Image sources:

  • https://www.gettyimages.in/detail/news-photo/circa-400-bc-hippocrates-an-ancient-greek-physician-and-the-news-photo/51242244

  • https://www.britannica.com/biography/Aristotle

  • https://commons.wikimedia.org/wiki/File:William_Bateson.jpg

  • https://www.researchgate.net/figure/Spectral-karyotyping-SKY-of-the-metaphase-spread-showing-derXtXq2p_fig2_281389775

  • https://www.ucl.ac.uk/~ucapikr/projects/Ana_staining_LitRev.pdf

  • https://www.researchgate.net/figure/Cytogenetic-analysis-G-banding-karyotype-from-a-peripheral-blood-metaphase-of-the_fig1_235520522

  • https://www.ucl.ac.uk/~ucapikr/projects/Ana_staining_LitRev.pdf                                      

  • https://www.britannica.com/biography/Gregor-Mendel

Instructor bio

Prof. NB Ramachandra

University of Mysore
Prof. NB Ramachandra (NBR) is a renowned academician with 28 years of teaching to his credit in various fields of Genetics. He completed his PhD from the University of Mysore and did his postdoctoral studies at McMaster University, Canada. Prof. NBR later worked as a Senior Research Associate II at the University of California, Los Angeles (1999-2000). He joined his alma mater in 1992 as a faculty of Zoology. He was instrumental in establishing the department of studies in Genetics and Genomics in 2015 and also was its founder-chairman. He is currently a UGC-BSR faculty and has authored and published more than 200 papers in international journals till date. He was the local secretary for the 103rd Indian Science Congress conducted at the University of Mysore. He has several accolades to his name and is the recipient of one national and two state science awards. He has also won a University of Mysore Golden Jubilee Foundation award. Prof. NBR is both an Elected Fellow of the Indian Academy of Sciences (FASc.2017) and Honorary Fellow of the Karnataka State Science and Technology Academy (2020 onward).

Course certificate

Assessment/Assignment marks will be considered for Internal Marks and will carry 30 percent for overall Result.

End Term Exam- will have 100 questions and will carry 70 percent of  overall Result.

*All students, who obtain 40% marks in in-course assessment and 40% marks in end-term proctored exam separately, will be eligible for certificate and credit transfer.

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