Human Genetics

By Prof. NB Ramachandra | University of Mysore

Learners enrolled: 769

The study of human genetics can be intellectually fascinating, but it also has plenty of practical applications. From the use of DNA in court cases to the discovery of new therapies for genetic diseases, a thorough understanding of the human genome can have important medical, social and legal impacts. Understanding the genetic basis behind human disease is one of the most important reasons for studying the human genome. While many genetic disorders are not treatable, early diagnosis can help improve the quality of life or even extend the lifespan of sufferers.

Current clinical trials on genetic therapies offer the promise of eventual treatments that may give sufferers a life free of symptoms. Diagnostic tests can help couples decide whether to risk passing on specific disease-related genes to their children. Tests assist in vitro fertility doctors to specifically select embryos that do not carry the dangerous gene.

Summary

Course Status :	Completed
Course Type :	Elective
Language for course content :	English
Duration :	12 weeks
Category :	Biological Sciences & Bioengineering
Credit Points :	4
Level :	Undergraduate
Start Date :	09 Jan 2023
End Date :	30 Apr 2023
Enrollment Ends :	15 Mar 2023
Exam Date :

Page Visits

Course layout

Day	Weekly Lecture Topics TITLE OF VIDEO LECTURE AND READING TEXT
Week 1	Episode 1	1 Introduction
	Episode 2	2 Dermatoglyphics 1
	Episode 3	3 Dermatoglyphics 2
Week 2	Episode 4	4. Pedigree analysis 1
	Episode 5	5. Pedigree Analysis 2
	Episode 6	6 Chromosomes
Week 3	Episode 7	7. Heterochromatin
	Episode 8	8. Ultrastructure of Chromosome
	Episode 9	9. Human Karyotype
	Episode 10	10 Banding techniques
Week 4	Episode 11	11. Euploidy and monoploidy
	Episode 12	12. Haploidy and polyploidy
	Episode 13	13. Anueploidy and nondisjunction
	Episode 14	14. Deletions with examples
Week 5	Episode 15	15. Duplications with examples
	Episode 16	16. Inversions with examples
	Episode 17	17. Translocations with examples
	Episode 18	18. Evolutionary significance of Chromosomal aberrations
Week 6	Episode 19	21 Genetic disease and inheritance pattern
	Episode 20	22.a)Autosomal dominant inheritance
	Episode 21	22.b)Autosomal recessive inheritance
Week 7	Episode 22	23. X- and Y-linked inheritance
	Episode 23	24. Multifactorial & mito diseases
	Episode 24	25. Oncogenetics
Week 8	Episode 25	26.Tumour suppressor genes
	Episode 26	27.Cells of immune system
	Episode 27	28. Genetics of immune system
Week 9	Episode 28	29. Innate adaptive immunity & I response
	Episode 29	30. Inherited Immunodeficiency
	Episode 30	31.a) HGPs i.e. Human Genome Projects
	Episode 31	31.b) HGPs i.e. Human Genome Projects
Week 10	Episode 32	32.Genetic markers-SNPs and applications
	Episode 33	33. Genetic markers-CNVs and InDels and their implications
	Episode 34	34. Prenatal diagnosis- Non-invasive methods
	Episode 35	35. Prenatal diagnosis- Invasive method
Week 11	Episode 36	36. Technology in reproductive assistance
	Episode 37	37. Gene therapy with reference to hemophilia
	Episode 38	38.Cord blood banking and stem cell therapy
Week 12	Episode 39	39.Genetic counseling
Week 12	Episode 40	40. Eugenics- positive and negative implications

Books and references

Books

Brooker, R. J. 2014. Genetics: Analysis and Principles. 5th edition. McGraw Hill.
Cavalli-Sforza L.L., Piazza A., Menozzi P. (1994) History and geography of genes. (Princeton University Press, Princeton, NJ).
Cummings, M. R. 2014. Human Heredity: Principles and Issues. West Publishing Company.
Gardner E. J. M. J. Simmons and D.P. Snustad. 2006 Principles of Genetics. 8th edition. John Wiley & Sons. INC. New York
Griffiths A J F, H. J. Muller, D. T. Suzuki, R. C. Lewontin and W. M. Gelbart. An introduction to genetic analysis.2015. 11th edition. W. H. Greeman. New York.
Harpending H., Sherry S.T., Rogers A.R., Stoneking M.(1993) The genetic structure of ancient human populations. Curr. Anthropol. 34:483–496.
Simmons S 2006, Principles of genetics, 4th Edition, John Wiley & Sons (Asia) Pte Ltd. New Jersey.
Strickberger M. W. 2012. Genetics. Mac Millan Publishing Co. NewYork
Tamarin, R H. 2009. Principles of Genetics. McGraw-Hill.

Image sources:

https://www.gettyimages.in/detail/news-photo/circa-400-bc-hippocrates-an-ancient-greek-physician-and-the-news-photo/51242244
https://www.britannica.com/biography/Aristotle
https://commons.wikimedia.org/wiki/File:William_Bateson.jpg
https://www.researchgate.net/figure/Spectral-karyotyping-SKY-of-the-metaphase-spread-showing-derXtXq2p_fig2_281389775
https://www.ucl.ac.uk/~ucapikr/projects/Ana_staining_LitRev.pdf
https://www.researchgate.net/figure/Cytogenetic-analysis-G-banding-karyotype-from-a-peripheral-blood-metaphase-of-the_fig1_235520522
https://www.ucl.ac.uk/~ucapikr/projects/Ana_staining_LitRev.pdf
https://www.britannica.com/biography/Gregor-Mendel

Instructor bio

Prof. NB Ramachandra

University of Mysore

Prof. NB Ramachandra (NBR) is a renowned academician with 28 years of teaching to his credit in various fields of Genetics. He completed his PhD from the University of Mysore and did his postdoctoral studies at McMaster University, Canada. Prof. NBR later worked as a Senior Research Associate II at the University of California, Los Angeles (1999-2000). He joined his alma mater in 1992 as a faculty of Zoology. He was instrumental in establishing the department of studies in Genetics and Genomics in 2015 and also was its founder-chairman. He is currently a UGC-BSR faculty and has authored and published more than 200 papers in international journals till date. He was the local secretary for the 103rd Indian Science Congress conducted at the University of Mysore. He has several accolades to his name and is the recipient of one national and two state science awards. He has also won a University of Mysore Golden Jubilee Foundation award. Prof. NBR is both an Elected Fellow of the Indian Academy of Sciences (FASc.2017) and Honorary Fellow of the Karnataka State Science and Technology Academy (2020 onward).

Course certificate

Assessment/Assignment marks will be considered for Internal Marks and will carry 30 percent for overall Result.

End Term Exam- will have 100 questions and will carry 70 percent of overall Result.

*All students, who obtain 40% marks in in-course assessment and 40% marks in end-term proctored exam separately, will be eligible for certificate and credit transfer.

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