Immunology

By Dr. Reena Haobam | Associate Professor, Department of Biotechnology, Manipur University

Learners enrolled: 1261

Immunology is the study of the immune system. The immune system is the body’s own defence mechanism to protect from various harmful microbial infections. A basic course in immunology is important for those students who opt for undergraduate and post graduate courses in biological sciences. The course focus on understanding basic immunology, and also discuss about various immunotechniques and their applications. The course covers discussions on the various components of the immune system, the activations of those components during immune response and the different types of immune responses. All the components of the immune system whether it’s the cells or organs, the different proteins or the various immuno mediators, they all work together to give a highly co-ordinated and interactive immune response to eliminate any foreign body that may be harmful to the body. The course also has discussions on some of the important immunotechniques like radioimmunoassay, ELISA, western blotting, fluorescence in situ hybridisation etc. It is a comprehensive course covering vast areas of immunology. On undergoing this course, the students will be learning the fundamental knowledge of immunology along with its importance and applications.

Summary

Course Status :	Completed
Course Type :	Core
Duration :	12 weeks
Category :	Biological Sciences & Bioengineering
Credit Points :	4
Level :	Undergraduate
Start Date :	23 Jan 2023
End Date :	30 Jun 2023
Enrollment Ends :	15 Mar 2023
Exam Date :

Page Visits

Course layout

Week 1:
1. Introduction to immune system
2. Organs of the immune system
3. Cells of the immune system
4. Antigens and immunogens

Week 2:
5. Structures of immunoglobulins
6. Generation of antibody diversity
7. Antigen-antibody interactions
8. T-Cell receptors (TCR)

Week 3:
9. MHC- molecules
10. Cytokines
11. Complement System –I Classical pathway
12. Complement System –II Alternative pathway

Week 4:
13. Antigen processing and presentation ( Antigen presenting cells-macrophages, dendritic cells)
14. Development of B cells and T cells
15. Types of immune response-I Innate and adaptive immunity
16. Types of immune response-II Humoral and cell mediated immunity

Week 5:
17. Types of immune response-III Primary and secondary immune response
18. Types of immune response-IV Clonal selection theory
19. Immunity to infection (Activation of B and T- cells)
20. Immune response to viruses

Week 6:
21. Immune response to bacteria
22. Immune response to parasites
23. Mediators of inflammation and leukocyte extravasations
24. Inflammation

Week 7:
25. Hypersensitivity reactions
26. Autoimmune diseases
27. Immunodeficiency diseases
28. Transplantation immunology

Week 8:
29. Immunohaematology
30. Immunotolerance
31. Vaccine
32. Immunochemical technique-I : Production of antibodies

Week 9:
33. Immunochemical technique-II: Immunodiffusion test
34. Immunochemical technique-III: Complement fixation test
35. Western blot analysis and Elisa
36. Immunochemical technique-V: Immuno- electrophoresis

Week 10:
37. Immunochemical technique-VI: Enzyme Linked Immunosorbant Assay (ELISA)
38. Immunochemical technique-VII: Assaya based on agglutination reactions
39. Immunochemical technique-VIII: Purification of immunoglobulins
40. Immunochemical technique-IX: Isolation of lymphocytes and macrophages

Books and references

REFERENCES:
Peter J. Delves, Seamus J. Martin, Dennis R. Burton & Ivan M Roitt. 2011: Roitt's essential immunology (12th ed) Hoboken, NJ: Wiley-Blackwell.

Kindt, T. J., Goldsby, R. A., Osborne, B. A., & Kuby, J. 2007: Kuby immunology (6th ed.). New York: W.H. Freeman

LINKS:

http://www.mcqbiology.com/2014/12/multiple-choice-questions-on-basic.html#.WTJzEdzYXIU

https://microbeonline.com/mcq-in-microbiology-immunology-questions-and-answers-with-explanation/

Instructor bio

Dr. Reena Haobam

Associate Professor, Department of Biotechnology, Manipur University

Dr. Reena Haobam has been working as an Associate Professor in the Department of Biotechnology, Manipur University since 2009. She was awarded the university gold medal in M.Sc. (Biochemistry) from Manipur University in 2002. Later, she received her Ph.D. Degree from Jadavpur University, Kolkata. She had worked in the Indian Institute of Chemical Biology (CSIR), Kolkata for her doctoral degree in the field of regenerative therapy for Parkinson’s disease using stem cells. Her research is mainly focused on the genomics of drug addiction and tuberculosis. She has successfully completed a DBT project on “Association of gene polymorphisms in DAT1 and OPRM1 with drug addiction in a population from Manipur”. At present she is handling two research projects: A multi-institutional DBT project on pharmacogenomics of Tuberculosis and genotyping of MDR-TB in north east India in which she is the project co-ordinator and PI. The other project is an IBSD-partnership programme where their research team works on identifying neuroprotective molecules from plant sources from the rich biodiversities of Manipur. She has many international research papers to her credit and has about 265 citations. She also has a US-patent application for “Treatment of brain Disorders”.