Human Genetics

By Prof. N. B. Ramachandra | University of Mysore

Learners enrolled: 1016

The study of human genetics can be intellectually fascinating, but it also has plenty of practical applications. From the use of DNA in court cases to the discovery of new therapies for genetic diseases, a thorough understanding of the human genome can have important medical, social and legal impacts. Understanding the genetic basis behind human disease is one of the most important reasons for studying the human genome. While many genetic disorders are not treatable, early diagnosis can help improve the quality of life or even extend the lifespan of sufferers.

Current clinical trials on genetic therapies offer the promise of eventual treatments that may give sufferers a life free of symptoms. Diagnostic tests can help couples decide whether to risk passing on specific disease-related genes to their children. Tests assist in vitro fertility doctors to specifically select embryos that do not carry the dangerous gene.

Summary

Course Status :	Ongoing
Course Type :	Elective
Duration :	12 weeks
Category :	Biological Sciences & Bioengineering
Credit Points :	4
Level :	Undergraduate
Start Date :	08 Jan 2024
End Date :	30 Apr 2024
Enrollment Ends :	29 Feb 2024
Exam Date :	25 May 2024 IST
Exam Shift :	Shift - 2

Note: This exam date is subjected to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Day	Weekly Lecture Topics TITLE OF VIDEO LECTURE AND READING TEXT
Week 1	Episode 1	1 Introduction
	Episode 2	2 Dermatoglyphics 1
	Episode 3	3 Dermatoglyphics 2
Week 2	Episode 4	4. Pedigree analysis 1
	Episode 5	5. Pedigree Analysis 2
	Episode 6	6 Chromosomes
Week 3	Episode 7	7. Heterochromatin
	Episode 8	8. Ultrastructure of Chromosome
	Episode 9	9. Human Karyotype
	Episode 10	10 Banding techniques
Week 4	Episode 11	11. Euploidy and monoploidy
	Episode 12	12. Haploidy and polyploidy
	Episode 13	13. Anueploidy and nondisjunction
	Episode 14	14. Deletions with examples
Week 5	Episode 15	15. Duplications with examples
	Episode 16	16. Inversions with examples
	Episode 17	17. Translocations with examples
	Episode 18	18. Evolutionary significance of Chromosomal aberrations
Week 6	Episode 19	21 Genetic disease and inheritance pattern
	Episode 20	22.a)Autosomal dominant inheritance
	Episode 21	22.b)Autosomal recessive inheritance
Week 7	Episode 22	23. X- and Y-linked inheritance
	Episode 23	24. Multifactorial & mito diseases
	Episode 24	25. Oncogenetics
Week 8	Episode 25	26.Tumour suppressor genes
	Episode 26	27.Cells of immune system
	Episode 27	28. Genetics of immune system
Week 9	Episode 28	29. Innate adaptive immunity & I response
	Episode 29	30. Inherited Immunodeficiency
	Episode 30	31.a) HGPs i.e. Human Genome Projects
	Episode 31	31.b) HGPs i.e. Human Genome Projects
Week 10	Episode 32	32.Genetic markers-SNPs and applications
	Episode 33	33. Genetic markers-CNVs and InDels and their implications
	Episode 34	34. Prenatal diagnosis- Non-invasive methods
	Episode 35	35. Prenatal diagnosis- Invasive method
Week 11	Episode 36	36. Technology in reproductive assistance
	Episode 37	37. Gene therapy with reference to hemophilia
	Episode 38	38.Cord blood banking and stem cell therapy
Week 12	Episode 39	39.Genetic counseling
Week 12	Episode 40	40. Eugenics- positive and negative implications

Books and references

Books

Brooker, R. J. 2014. Genetics: Analysis and Principles. 5th edition. McGraw Hill.
Cavalli-Sforza L.L., Piazza A., Menozzi P. (1994) History and geography of genes. (Princeton University Press, Princeton, NJ).
Cummings, M. R. 2014. Human Heredity: Principles and Issues. West Publishing Company.
Gardner E. J. M. J. Simmons and D.P. Snustad. 2006 Principles of Genetics. 8th edition. John Wiley & Sons. INC. New York
Griffiths A J F, H. J. Muller, D. T. Suzuki, R. C. Lewontin and W. M. Gelbart. An introduction to genetic analysis.2015. 11th edition. W. H. Greeman. New York.
Harpending H., Sherry S.T., Rogers A.R., Stoneking M.(1993) The genetic structure of ancient human populations. Curr. Anthropol. 34:483–496.
Simmons S 2006, Principles of genetics, 4th Edition, John Wiley & Sons (Asia) Pte Ltd. New Jersey.
Strickberger M. W. 2012. Genetics. Mac Millan Publishing Co. NewYork
Tamarin, R H. 2009. Principles of Genetics. McGraw-Hill.

Image sources:

https://www.gettyimages.in/detail/news-photo/circa-400-bc-hippocrates-an-ancient-greek-physician-and-the-news-photo/51242244
https://www.britannica.com/biography/Aristotle
https://commons.wikimedia.org/wiki/File:William_Bateson.jpg
https://www.researchgate.net/figure/Spectral-karyotyping-SKY-of-the-metaphase-spread-showing-derXtXq2p_fig2_281389775
https://www.ucl.ac.uk/~ucapikr/projects/Ana_staining_LitRev.pdf
https://www.researchgate.net/figure/Cytogenetic-analysis-G-banding-karyotype-from-a-peripheral-blood-metaphase-of-the_fig1_235520522
https://www.ucl.ac.uk/~ucapikr/projects/Ana_staining_LitRev.pdf
https://www.britannica.com/biography/Gregor-Mendel

Instructor bio

Prof. N. B. Ramachandra

University of Mysore

Prof. N. B. Ramachandra completed his Ph.D. from University of Mysore and postdoctoral studies from McMaster University, CANADA from 1990-1992 and Worked as Senior Research Associate II at Univ. of California, Los Angeles, USA from 1999-2000. He joined as a faculty of Zoology at the University of Mysore during 1992. He was instrumental to establish the new department of studies in Genetics and Genomics during 2015 and also, he was the founder Chairman of the Department of Studies in Genetics and Genomics. Currently he is holding the position of prestigious DAE- Raja Ramanna Chair for five years. He has completed successfully three years of UGC-BSR faculty fellowship after his retirement during 2020. He has published more than 200 papers in International journals and during 2016; he served as the Local Secretary for 103rd Indian Science Congress conducted at the University of Mysore. He is the recipient of several awards including University of Mysore Golden Jubilee foundation award, the two state and one national science awards. He is an Elected Fellow of the Indian Academy of Sciences (FASc.2017), Honorary Fellow of the Karnataka State Science and Technology Academy 2020 onward and in 2023, he is an elected Fellow of Indian Academy of Biomedical Sciences.He has 31 years of teaching experience in the various fields of Genetics in University of Mysore and other Universities and Institute. For more details, one can see his profile in his web page: http://www.ramachandralab.com

Course certificate

Assessment/Assignment marks will be considered for Internal Marks and will carry 30 percent for overall Result.

End Term Exam- will have 100 questions and will carry 70 percent of overall Result.

*All students, who obtain 40% marks in in-course assessment and 40% marks in end-term proctored exam separately, will be eligible for certificate and credit transfer.

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