Biomolecules : Structure Function In Health And Disease

By Dr. Ashok Sharma | All India Institute of Medical Sciences (AIIMS), New Delhi

Learners enrolled: 742

This course on Biomolecules is one of the basic course for all PG Students of Biological Sciences. This is 4 credit course. Gives an overview of importance of biomolecules starting from the simplese molecule, water. Elaborate the need to study proteins: Their 3D Structure,protein seperation,sequencing etc. To understand the pathology and identifying biomrakers using clinical proteomics. Explain in detail DNA,RNA their structures, interactions role in disease,genomics.epigenetics. Enumerate the role of carbohydrates,lipids and their cellular function in physiology and pathology. To briefly introduce to system biology

Summary

Course Status :	Ongoing
Course Type :	Core
Duration :	15 weeks
Category :	Biological Sciences & Bioengineering
Credit Points :	4
Level :	Postgraduate
Start Date :	09 Jan 2024
End Date :	30 Apr 2024
Enrollment Ends :	29 Feb 2024
Exam Date :	26 May 2024 IST
Exam Shift: :	Shift-II

Note: This exam date is subjected to change based on seat availability. You can check final exam date on your hall ticket.

Page Visits

Course layout

Week 1

Chemical bonds:Different types of Bonds, Bond energies,Bond Angles etc, Water:The molecule of life,Aqueous Solution,Acids & Bases,Measurements of pH, Henderson Haselbatch equation,Titration Curve & pK values,Buffers

Week 2

Amino acids, chirality, peptide bond and polypeptides,Structural levels of proteins and Stabilizing forces,Conformational properties of polypeptides and Ramachandran plot

Week 3

Turns, loops, Super secondary structures, motifs and domains in proteins,Structures and function of Fibrous Proteins,Structure and function of Actin and myosins

Week 4

Hemoglobin, Myoglobin and Oxygen binding,Role of Protein Structure in Health and Disease,Assessment 1

Week 5

Protein Seperation Techniques: Centrifugation & Chromatography,Protein sequencing

Week 6

Methods of structure determination of proteins : X-ray, NMR, CD etc,Clinical Proteomics

Week 7

Antigen-Antibody Complex and their Applications in Immunology,Protein-Ligand(Small Molecules including drugs) interaction

Week 8

Components of Nucleic Acids,Conformational parameters of Nucleic acids and DNA double helix,DNA Polymorphism

Week 9

Circular DNA,Supercoil DNA

Week 10

Interactions of small molecules (ions, drugs ) with DNA,Different types and structures of RNA

Week 11

DNA-Protein interactions,Assessment 2

Week 12

Introduction to Carbohydrates,Structures of polysaccharides,Saturated and unsaturated fatty acids, Nomenclature of fatty acids and Essential and non-essential fatty acids

Week 13

Glycoproteins and Proteoglycons,Classification of Lipids: simple and compound lipids, phospholipids, Cholesterol,Micelles and Liposomes : Applications in biology and medicine

Week 14

Lipids: extraction, separation and analysis,Components and architecture of Cell membrane,Various membrane models including Fluid-mosaic model

Week 15

Cholesterol and its role in health and disease,Interrealtionship of Biomolecules : System Biology,Epigenetics and Human Diseases,Final Assessment

Books and references

1. An Introduction to Biophyics by Moganty R Rajeswari, 2013.

2. Biophysical Chemistry,Part II, Techniques for the study of biological structure and function,by Cantor C.R. and Schimmel P R., W.H. Freeman and Company, 1980.

3. Nucleic Acids in chemistryand Biology,by Blackburn G.M. and gait M.J.,IRL Press,1990.

4. Biochemistry, by Voet D. and Voet J.G., John Wiley and sons, 1995.

5. Physical Biochemistry, by Freifelder D., W.H. Freeman and company, 1976-1982.

Instructor bio

Dr. Ashok Sharma

All India Institute of Medical Sciences (AIIMS), New Delhi

Dr. Ashok Sharma

Additional Professor

DBT-Ramalingaswami Fellow

DST-Ramanujan Fellowship Awardee

Department of Biochemistry,

AIIMS, New Delhi, Bharat

A skilled Researcher with an International track record of success in a progressively responsible position in a clinical research environment. Dr. Sharma is involved in developing ‘Translational Cancer Research’ & ‘Molecular Diagnostic’ at National Cancer Institute-India, AIIMS, Jhajjar campus, Haryana. He is a highly motivated team leader experienced in both In-vivo and In-vitro Molecular Biology and Cancer epigenetics & DNA methylation lab settings and have experience in Pharmacology & Toxicology field as a pharmacist. Major areas of his experience, strengths, and skills include cancer epigenetics, DNA methylation, Cancer- germline antigen, Pyro-& Oxford Nano sequencing, cell signaling; cell signaling; EMT, drug metabolism; working knowledge of pharmacological assays, clinical trials; ability to manage projects and personnel with enthusiasm and team-oriented perspective. He is a prestigious “DBT- Ramalingaswami fellowship” and “DST-Ramanujan fellowship" awardee from Govt. of India. He is a motivated and driven individual, and he aspires to enhance his knowledge in the DNA methylation & genomic Instability' field through valid scientific investigation. Adept in driving thought-provoking class debates to promote student engagement in research & learning. He is a collaborative team player, acting as a key resource to colleagues and allied health professionals. Dr. Sharma has several publications in journals of national and international repute. As far his researcher index is concerned, he has an i10 index of 23 and h-index of 19 with a total citations of 1450+.

Google scholar id: https://scholar.google.co.in/citations?user=3ac275cAAAAJ&hl=en

Webspace id: https://www.epigeneticslab-aiims.info/