The course “Cytoenetics” is a core course in B.Sc. Medical sciences and M. Sc Zoology, M. Sc Botany and M. Sc Bioresources under the Choice Based Credit System (CBSE). The course is specially designed to supplement and enhance the understanding of students about different dimensions of Cytogenetics
| Course Status : | Upcoming |
| Course Type : | Core |
| Language for course content : | English |
| Duration : | 12 weeks |
| Category : |
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| Credit Points : | 4 |
| Level : | Undergraduate/Postgraduate |
| Start Date : | 07 Jul 2025 |
| End Date : | 31 Oct 2025 |
| Enrollment Ends : | 31 Aug 2025 |
| Exam Date : | |
| NCrF Level : | 4.5 |
WEEK 1
1. Historical perspective of cells, cell theory and exceptions to cell theory
2. A detail classification of cell types within an organism; cell, tissue, organ and organisms as different levels of organization.
3. Overview of prokaryotic and eukaryotic (plants and aimals) cells
4. Structure of viruses - general structure, properties of viral envelopes and enzymes (principles of virus taxonomy)
WEEK 2
5. Overview of phages, virioids, mycoplasma and Escherichia coli
6. Structure, properties and functions of the immune cells & organs - hematopoeisis, T and B lymphocyte, NK cells, monocyte and macrophages
7. Structure, properties and functions of the immune cells & organs - neutrophils, eosinophils, basophils, mast cells and dendritic cells
8. Structure, properties and functions of the immune cells & organs - thymus and bone marrow; lymph nodes, spleen, MALT, GALT and SALT
WEEK 3
9. Mitosis and meiosis: interrelation between the cell structure and the genetic function, mitosis, meiosis.
10. Linkage, crossing over and chromosomal mapping
11. Cytological basis and molecular mechanism of crossing over (recombination frequency as a measure of linkage intensity, two factor and three factor crosses, interferance and coincidence, somatic cell genetics – an alternative approach to gene mapping)
12. Chromosomal mechanisms and environmental factors determining sex (Barr bodies, dosage compensation)
WEEK 4
13. Gametogenesis and fertilization: structure and production of gametes, zygote formation
14. Functional organization of the cell nucleus: chromatin movements, nuclear bodies and its significance.
15. Chromosomal mutations: deletion, duplication, inversion, translocation, aneuploidy and polyploidy; gene mutations: induced versus spontaneous mutations, back versus suppressor mutations, molecular basis of mutatons in relation to UV light and chemical mutagens. Detection of mutations: CLB method, Attached X method
16. Microscopy and its types: principles of light microscopy, phase contrast, confocal microscopy. Electron microscopy (EM) - scanning EM and scanning transmission EM (STEM), fluorescence microscopy
WEEK 5
17. Biochemical techniques Part I and Part II
18. Sub-cellular fractionation (differential and density gradient centrifugation)
19. Cell fixation and staining: freeze-drying and free-substitution, microtomes and embedding, chemical basis of staining, metachromasia
20. Human karyotype
WEEK 6
21. Human cytogenetics technique: Fluorescence In Situ Hybridization (FISH)
22. Advanced Techniques in Chromatography and Their Applications
23. General characteristics of cell differentiation
24. Molecular mechanism of cell differentiation
WEEK 7
25. Chemical composition and properties of membrane components
26. Selective permeability of the membranes, membrane transport
27. Cell wall, extracellular matrix
28. Plasma membrane and membrane transport
WEEK 8
29. Phagocytosis, pinocytosis and exocytosis.
30. Nuclear structure and functions
31. Nuclear lamina, transport across nuclear envelope, Chromatin: molecular organization
32. Nucleolus and rRNA processing.
WEEK 9
33. Genome sequence and chromosome diversity, chromosome duplication and segregation, And nucleosome.
34. Chromatin structure
35. Regulation of chromatin structure and nucleosome assembly, organisation of chromosomes
36.Human chromosomal abnormalities: aneuploidy, reciprocal translocations, sex chromosomal abnormalities and autosomal abnormalities (mongolism)
WEEK 10
37. Cell Biology
38. Endoplasmic reticulum, Golgi apparatus, Mechanism of vesicular transport and lysosomes
39. Mitochondria and chloroplast DNA
40. Extra-chromosonal inheritance
WEEK 11
41. Mitochondrial mutations, Maternal effects and ineffective heredity
42. Cytoskelton and Cell movement
43. Intermediate filaments, microtubules
44. Signaling molecules and their receptor; functions of cell surface receptors
WEEK 12
45. Cell cycle
46. Carcinogenesis Characteristics of cancerous cells Process of Carcinogenesis
47. Common chromosome abnormalities in cancer
Dr. Md. Niamat Ali, Associate Professor (Zoolgy: Cytogenetics and Molecular Biology), Centre for Research and Development, University of Kashmir, Srinagar-190 006, J & K, India
Email ID: mdniamat@hotmail.com mdniamat@gmail.com mdniamat@uok.edu.in
Dr. Md. Niamat Ali did his M.Sc from University of Burdwan, West Bengal, India; M.Phil and Ph.D from Aligarh Muslim University, Aligarh-202002, U. P., India.
ACADEMIC HIGHLIGHTS AT A GLANCE
Teaching Experience: 20 years (A. M. U, Aligarh- 06 years and Kashmir University, Srinagar - 14 years)
Research Experience: 25 years
Major Field of Research and Teaching Interest: Cytogenetics, Molecular Biology and Immunogenetics; Toxicogenomics; Human Genomics and Proteomics; Stem Cell Biology and Regenerative Medicine; Radiation Biology and Gene Therapy; Cell and Tissue Culture Technology and Ageing Biology; PCR and DNA Fingerprinting Technology, FISH Technology and Comet Assay; Biostatistics
Invited Talks Delivered as a Resource Person: 10
Research Papers Presented/ Participated in Seminar/ Symposium (Oral/ Poster): 10
Review Articles Contributed for the Guide Books Edited for the Participants of Workshops: 10
Reviewer of Academic Video Documents, E-module Content for Biomedical Science, Assigned by Educational Multimedia Research Centre, University of Kashmir, Srinagar, J & K, India: 35
Workshop/Conferences/Seminar Organized: 01
Executive Editor of Journal/ Editor Souvenir and Abstract Book for Seminar and Conference/ Workshop Guide Books: 11
Number of M. Phil produced: 07
Number of Ph. D awarded/ submitted: 03
Number of Ph. D Scholars presently working under supervision: 08
Research Papers Published in National and International Journals of Repute: 46 [Chromosoma (Springer Verlag: IF = 4.196); Journal of Ethnopharmacology (Elsevier : IF = 3. 728); Chemosphere (Elsevier: IF = 3.613); Mutation Research/Genetic Toxicology and Environmental Mutagenesis (Elsevier: IF = 3.175); Ecotoxicology and Environmental Safety (Academic Press: IF = 2.718); Microbial Pathogenesis (Elsevier: IF: 1.888 ); Indian Journal of Experimental Biology (NISCAIR, CSIR, New DelhiI: IF = 1.295); Toxicological and Environmental Chemistry (Taylor and Francis: IF = 1. 020); Mitteilungen der Schweizerischen Entomologischen Gesellschaft. Bulletin de la Societe Entomologique Suisse (Schaffhausen puis Lausanne puis Zürich: IF = 0. 764; Saudi Journal of Biological Sciences (Elsevier: IF = 0.741); Journal of Scientific and Industrial Res (NISCOM, CSIR, New Delhi: IF = 0.5); Journal of Clinical Toxicology (OMICS International, Online Journal, USA, etc]
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