Week 1: Elements Of Heredity And Variations
1. Historical Background and Mendel’s Laws of Inheritance: Part 1
2. Historical Background and Mendel’s Laws of Inheritance: Part 2
3. Understanding Mendel’s Data: Methods & Applications (Probability, Product Rule, Sum Rule, Binomial Expansion and Factorial)
4. Understanding Mendel’s Data: Methods & Applications (Punnet Square, Forked Line Method, Statistical Test to Analyze Data)
5. Chromosomal Basis of Inheritance (Post Mendel’s laws, chromosome behavior during meiosis, theory by Sutton and Boveri, Work of Morgan and team)
Week 2: Extension of Mendelism
1. Dominance Relationships, Multiple Allelism
2. Multiple Allelism, Conditional Alleles, Lethal Alleles
3. Pleiotropy, Phenocopy, Polygeny
4. Epistasis
5. Gene Interaction
Week 3: Various Ways To Determine Sex And Inheritance Of Sexual Traits
1. Discovery of Sex Chromosomes: From History to Systems
(XX/XY system in Drosophila and Human)
2. Discovery of Sex Chromosomes: From History to Systems (XX/XO, ZZ/ZW, haploidy/diploidy)
3. Environmental and Hormonal control of sex determination
4. Sex Influenced, Sex-Limited and Sex Linked Traits
5. Dosage Compensation in Drosophila and Human
Week 4: Different Types Of Inheritance Patterns
1. Quantitative Inheritance
2. Quantitative Inheritance (Cont.)
3. Extra nuclear inheritance
4. Infective Inheritance
5. Maternal Inheritance
Week 5: Gene Mutations
1. Spontaneous Mutations
2. Induced Mutations
3. Molecular basis of mutations
4. Detections of mutations, Ames test, ClB technique, Nutritional Mutations in Neurospora
5. DNA repair mechanisms
Week 6: Gene Mapping In Prokaryotes
1. Bacterial Growth and Conjugation
2. Conjugation And Sexduction: Gene Mapping in Bacteria
3. Transformation: Gene Mapping in Bacteria
4. Transduction and Gene Mapping in Bacteria
5. Gene mapping in Phages: Mapping the rII Locus – History, Concepts & Applications
Week 7: Gene Mapping On Eukaryotic Chromosomes
1. Linkage and Crossing over: Concepts in Classical & Molecular Genetics
2. Recombination and Cytological Determination of Crossing over
3. Gene Mapping Using Two point and three Point Test Cross
4. Interference and Coincidence
5. Gene Mapping in yeast and Neurospora Using Tetrad Analysis Methods
Week 8:Chromosomal alterations
1. Anomalies in chromosome number: Aneuploidy
2. Anomalies in chromosome number: Polyploidy
3. Anomalies in chromosome structure: Deletions and duplications
4. Meiotic consequences in inversion heterozygotes
5. Meiotic consequences in inversion heterozygotes
Week 9: Human Genetics: Pedigree Analysis
1. Making A Pedigree Chart and showing dominant and recessive traits
2. Study Of Autosomal Traits In A Pedigree
3. Study Of Sex-Linked Traits In A Pedigree
4. Study Inheritance Of Mitochondrial Traits In A Pedigree
5. Genetic Counselling
Week 10: Human Genetics: Chromosome Analysis
1. Human karyotyping
2. G-banding
3. Chromosome badings other than G-banding
4. Fluorescence in situ hybridization
5. Nomenclature of G-ban
Week 11: Human Genetics: Genetic Disorders
1. Human genetic disorders: Gene mutations
2. Human genetic disorders: Chromosomal aneuploidy
3. Human genetic disorders: Chromosome translocations
4. An introduction to cancer
5. An introduction to cancer with special reference to Human papilloma virus papilloma virus
Week 12: Regulation Of Gene Activity In Eukaryotes
1. Regulation of gene activity in eukaryotes: Transcription unit
2. Regulation of gene activity in eukaryotes: Initiation, elongation and termination of transcription
3. Regulation of gene activity in eukaryotes: Activators, enhancers and boundary elements
4. Regulation of gene activity in eukaryotes: RNA processing
5. Regulation of gene activity in eukaryotes: RNA editing, epigenetic modifications
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