Organic Chemistry-I

By Dr. B. S. Balaji   |   Jawaharlal Nehru University, New Delhi

Number of Credits =4

This course is a 4 credit course (15 weeks, 40 module) for M. Sc. Chemistry Students. Here, Students will be trained to improve their factual, conceptual, procedural and metacognitive knowledge. The scientific explanation given in the video contents makes use of the following components: Presentations, chemical structures, figures, tables, images, 3D-animations, white board demonstration, use of molecular models, paper 3D-models, mirrors etc. We gave emphasis to instructional design by leveraging theories based on Malcom  Knowels Andragogy, modified Bloom’s taxonomy, the Feynman Technique, ADDIE model, Dick and Carey model, neuro slide design principles etc.

Learners enrolled: 3592


Course Status : Completed
Course Type : Core
Duration : 15 weeks
Start Date : 15 Jul 2019
End Date : 30 Oct 2019
Exam Date : 10 Nov 2019
Enrollment Ends : 11 Sep 2019
Category :
  • Chemical Engineering
  • Chemistry
  • Level : Postgraduate


    Week 1 

    Introduction to stereochemistry Conformational analysis of open chain systems Conformational analysis of cyclic systems

    Week 2 

    Symmetry elements, Point group analysis Stereochemical conventions 

    Week 3 

    Stereogenicity, Topicity ORD and CD, Axial halo ketone rule, Octant Rule

    Week 4

    Stereochemical reactions Reactions involving stereo centres Crams Rule, Felkin-Anh model, Prelog rules

    Week 5

    Aromaticity, Aromatic stabilization energy, Hückel MO, Musulin-Frost diagram Polycyclic aromatic hydrocarbon (PAH), Polyacenes, Annulene

    Week 6 

    Aromatic Electrophilic substitutions Aromatic Nucleophilic substitutions Ipso-cine-tele substitution

    Week 7

    Reaction dynamics, Hammond postulate Linear free energy relationship, Hammett equation

    Week 8

    Yukawa Tsuno equation, Swain-Lupton equation, Grunwald–Winstein equation, Taft equation Curtin-Hammett principle, Winstein-Holness equation 

    Carbocation, Part 1: Generation, Structure and Geometry

    Week 9

    Carbocation, Part 2: Stabilisation of carbocation, Reactions

    Carbocation, Rearrangement 1: No Change in carbon skeleton, Change in carbon skeleton 

    Carbocation, Rearrangement 2: involvement of other electron deficient terminus, Anchimeric assistance

    Week 10

    Carbanions: pKa and its significance

    Carbanions: Hard and Soft Acid and Base principle

    Carbanions: Structure, Formation, Stability, Reactivity

    Week 11

    Carbanion reactions: Acyl Anions, Benzoin condensation, Umpolung-inversion of reactivity

    Free radical 1: Formation, Structure, Stability

    Free radical 2: Stability, Reactivity

    Week 12

    Free radical 3: Reactions

    Carbene, Nitrene: Generation, Structure, Reactivity

    Week 13

    Carbonyl addition reaction

    Week 14

    Carbonyl addition reaction

    Week 15

    Name reactions



    March's Advanced Organic Chemistry Reactions, Mechanisms and Structure 5th Ed. Michael B. Smith, Jerry March, John Wiley & Sons, Inc., 2001.

    F. A. Carey: Organic Chemistry, 5th  Ed., McGraw-Hill, 2004.

    Peter Sykes, A Guidebook to Mechanism in Organic Chemistry, 6th Ed, John Wiley and Sons. Inc, New York, 1986.

    J. Clayden, N. Greeves, S. Warren, Organic Chemistry, 2nd Ed., Oxford University Press, New Delhi, 2012.

    F. A. Carey and R. J. Sundberg, Advanced Organic Chemistry, Part A & B, 5th  Ed., Springer, New York, 2007.

    Thomas H. Lowry and Kathleen Schueller Richardson, Mechanism and theory in Organic Chemistry, Harper& Row, Publishers, 1976.

    Paula Yurkanis Bruice, Organic Chemistry, 4th Ed. Prentice Hall, 2003.

    Arvi Rauk, Orbital Interaction Theory of Organic Chemistry, 2nd Ed., John Wiley & Sons, Inc., 2001.

    D. Nasipuri, Stereochemistry of organic compounds, Principles and Applications, 3rd Ed. New Age International Publishers, 2018.

    P. S. Kalsi, Stereochemistry: Conformation and Mechanism, 9th Ed, New Age International (P) Ltd., 2017.

    Ernest L. Eliel, Samuel H. Wilen, Stereochemistry of Organic Compounds, Wiley India Ed, 2008.

    I. L. Finar, Organic Chemistry, Volume 2: Stereochemistry and The Chemistry of Natural Products, Chapter 2, 5th Ed, Pearson Education India, 1956.


    Dr. B S Balaji
    School of Biotechnology 
    Jawahar Lal Nehru University (JNU)

    Currently Dr. Balaji is serving as subject matter expert/external Academic consultant to e-VidyaBharati/ ArogyaBharati project of Ministry of External affairs, Government of India in collaboration with National Institute for Smart Governance. 
    Dr. Balaji is working as Associate Professor at School of Biotechnology, Jawaharlal Nehru University. His area of specialization includes Green chemistry, synthetic chemistry, drug development, nano-chemistry, teaching and learning methodologies. He received his Ph.D in organic Chemistry from National Chemical Laboratory, Pune, affiliated to then Pune University. He spent three years as Center of Excellence Foreign Visiting researcher at Hokkaido University, Sapporo, Japan. He then worked as Postdoctoral fellow and Research fellow (faculty track position) at University of Missouri, Columbia, USA for five years. He had published 18 research publications (including a book) and holds four Indian patents. The research contribution from his laboratory had appeared in few Journal cover pages (Chemical Communication, Nuclear Medicine and Biology) and appeared in local print and electronic media. He got his MBA from Anna University with Technology management as specialization.


    “30 Marks will be allocated for Internal Assessment and 70 Marks will be allocated for external proctored examination”